10
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5480 | BI-4464 | FAK , Ligands for Target Protein for PROTAC | |
BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC | |||
T2110 | (+)-JQ-1 | JQ1 | Epigenetic Reader Domain , Autophagy , Ligands for Target Protein for PROTAC |
(+)-JQ-1 (JQ1) is a BET bromine domain inhibitor that inhibits BRD4 (1/2) (IC50=77/33 nM) with specificity and reversibility. (+)-JQ-1 induces cell autophagy and inhibits cell proliferation. | |||
T10359 | AR antagonist 1 | Androgen Receptor , Ligand for E3 Ligase , Ligands for Target Protein for PROTAC | |
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266. | |||
T12186 | Navitoclax-piperazine | ABT-263-piperazine | BCL , Ligands for Target Protein for PROTAC |
Navitoclax-piperazine (ABT-263-piperazine) is an inhibitor of B-cell lymphoma extra large (BCL-XL). | |||
T1835 | Ibrutinib | PCI-32765 | Tyrosine Kinases , Src , BTK , Ligands for Target Protein for PROTAC |
Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation. | |||
T39910 | Desmorpholinyl Navitoclax-NH-Me | Desmorpholinyl ABT-263-NH-Me,Desmorpholinyl Navitoclax-NH-Me | BCL |
Desmorpholinyl Navitoclax-NH-Me (Desmorpholinyl ABT-263-NH-Me) is a Bcl-xL inhibitor, which can be employed alongside a CRBN ligand to synthesize XZ739, a PROTAC BCL-XL degrader [1] [2]. | |||
T19301 | DUPA | N,N''-Carbonylbis[L-glutamic acid],(2S,2'S)-2,2'-Carbonylbis(Azanediyl)Dipentanedioic Acid | Others , Ligands for Target Protein for PROTAC |
DUPA (N,N''-Carbonylbis[L-glutamic acid]) is used as the targeting moiety to actively deliver DTX for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer. | |||
T2066 | Quizartinib | AC220 | Apoptosis , FLT , Autophagy , Ligands for Target Protein for PROTAC |
Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases. | |||
T14593 | Biotin-PEG3-Mal | Others | |
Biotin-PEG3-Mal is a biotinylated polyethylene glycol (PEG) derivative used as a linker in the synthesis of proteolysis targeting chimeras (PROTACs). By introducing the biotin moiety, it enables specific recognition and ... | |||
T82870 | Biotin-PEG-Alk (MW 3400) | ||
Biotin-PEG-Alk (MW 3400), a biotinylated polyethylene glycol (PEG) compound with an alkyne group, serves as a versatile click chemistry reagent. The biotin moiety acts as an enzyme cofactor desirable for protein labeling... |